Search results for " Intratympanic"

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Cell-specific accumulation patterns of gentamicin in the guinea pig cochlea.

2015

Intratympanic gentamicin therapy has become a popular treatment modality for Meniere's disease (MD) through controlled elimination of vertigo spells caused by the balance organ. However, the known ototoxic properties of aminoglycosides lead to cochlear damage. In order to gain more information about cellular preferences for aminoglycoside accumulation within the cochlea, gentamicin was immuno histochemically localized by light microscopy in male guinea pigs 1 and 7 days after intratympanic application (n = 8 ears/incubation time). Differences in the gentamicin-specific cellular storage capacities were quantified by determination of the local immuno staining intensities. Gentamicin was detec…

MalePathologymedicine.medical_specialtyCell typeGuinea PigsBiological Transport ActiveBiologyotorhinolaryngologic diseasesmedicineAnimalsHumansTissue DistributionSpiral ganglionCochleaMeniere DiseaseInjection IntratympanicAminoglycosideGap JunctionsAnatomyImmunohistochemistrySensory SystemsStainingCochleamedicine.anatomical_structureOrgan of CortiSpiral ligamentModels AnimalGentamicinsense organsGentamicinsmedicine.drugHearing research

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